Hydrochloric Acid → HCID 136008001, compound

Participants

Reaction Steps

N-(2-Butyl-4-cyano-5-methyl-2H-pyrazol-3-yl)-2-fluoro-benzamide (4.0 g, 13.3 mmole) was suspended in 26 ml 1M sodium hydroxide, added 30% hydrogen peroxide (10 ml) and ethanol (5 ml). Heated the reaction mixture to reflux for 4 hours, then added more 30% hydrogen peroxide (10 ml) and heated to reflux overnight. Cooled reaction mixture and acidified with dilute hydrochloric acid to pH 6.0. Collected product by filtration and dried under vacuum to obtain 1.29 g product (yield: 32%).

Provenance & Evidence