N,N-Dimethylaniline → HCID 21104340, compound

Participants

Reaction Conditions

Reaction Steps

2-(5-Chloro-2-fluoro-phenyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one (60 mg, 0.228 mmole) was added to phosphorous oxychloride (1 ml). Added 57 microliters N,N-dimethylaniline (catalyst) and heated to 110° C. overnight. Removed excess phosphorous oxychloride under vacuum, residue treated with ice, and product extracted with chloroform. Dried chloroform extract over sodium sulfate (anh.) and removed solvent to give crude product. Product was purified by silica gel chromatography eluted with chloroform to give 36 mg product (yield: 56%).

Provenance & Evidence