HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1354314Generated: October 26, 2026
Hydrochloric Acid → 4-[6-(5-Chloro-2-fluoro-phenyl)-3-methyl-isoxazolo[5,4-d]pyrimidin-4-ylamino]-nicotinic acid
https://huagongshe.com/reaction/1354314
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[6-(5-Chloro-2-fluoro-phenyl)-3-methyl-isoxazolo[5,4-d]pyrimidin-4-ylamino]-nicotinic acid methyl ester | HCID 58865959 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[6-(5-Chloro-2-fluoro-phenyl)-3-methyl-isoxazolo[5,4-d]pyrimidin-4-ylamino]-nicotinic acid | HCID 21104333 | 27% |
Reaction Steps
4-[6-(5-Chloro-2-fluoro-phenyl)-3-methyl-isoxazolo[5,4-d]pyrimidin-4-ylamino]-nicotinic acid methyl ester (525 mg) was suspended in methanol (4 ml) added 1M sodium hydroxide solution (4 ml) and heated to 70° C. for 30 min. Removed methanol under vacuum and acidified solution to pH 4 with 6M hydrochloric acid. Filtered solid, washed with water and oven dried to give 137 mg product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07223766B2 |
|---|
| Source dataset | uspto-grants-2007_05 |
|---|
| ORD ID | ord-95f3b5a5282a4786997e801adc88ae8a |
|---|
| Source note | uspto-grants-2007_05 |
|---|
