3-(4-Hydroxyphenyl)propionic acid → HCID 10267466, compound

HRID 1354383Notes

Reaction equation

HRID 1354383 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.[CH3:13][O:14][C:15](=[O:22])[C@H:16]([CH2:18][CH2:19][S:20][CH3:21])[NH2:17]>>[CH3:13][O:14][C:15](=[O:22])[CH:16]([NH:17][C:10](=[O:12])[CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1)[CH2:18][CH2:19][S:20][CH3:21]

Participants

3

Reactant 2

HCID 103943-(4-Hydroxyphenyl)propionic acidHCID 64684methyl (2S)-2-amino-4-(methylsulfanyl)butanoate

Product 1

HCID 10267466HCID 10267466, compoundYield 91%

Procedure

Following the same procedure of Example 4 except that 3-(4-hydroxyphenyl)propionic acid (1.0 g, 6.0 mmol) and methionine methyl ester (1.08 g, 6.6 mmol) were used, 1.7 g of the title compound was obtained. The compound was finally purified by silica gel column chromatography (column size: 25 mm×150 mm, silica gel 70-230 mesh, eluent: hexane/EtOAc (1/1)). The results of analyses of the compound are as follows:

Sources & evidence

ORD record
ord-c869fe7e031540f097b616b4b17c2375
Source dataset
uspto-grants-2007_05
Patent number
US07223793B2

Reaction notes

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