Hydrochloric Acid → HCID 10447209, compound

Participants

Reaction Steps

2-[3-(3,4-dihydroxyphenyl)propionylamino]-4-methyl pentanoic acid methyl ester (200 mg), prepared in Example 13, was dissolved in tetrahydrofuran (5 mL) and treated with 2M lithium hydroxide (1 mL). The resulting mixture was stirred for 18 hours at room temperature. The resulting reaction was neutralized with aqueous hydrochloric acid, extracted with ethylacetate (EtOAc) (100 mL), dried over magnesium sulfate, concentrated under reduced pressure and purified by silica gel column chromatography (column size: 25 mm×150 mm, silica gel 70-230 mesh, eluent: hexan/EtOAc (1/5)) to obtain 184.5 mg of the title compound. The yield was 97%. The results of analyses of the compound are as follows:

Provenance & Evidence