反应详情

温度

60 °C

(S)-α-(Chloromethyl)benzenemethanol (2.38 g) in dry DMSO (50 ml) was treated with sodium azide (1.48 g) with stirring then heated at 60° C. for 24 h. More sodium azide (74 mg) was added and heating continued at 80° C. for a further 24 h. The reaction mixture was cooled, poured into water and extracted into ethyl acetate, which was washed with water (3×) then brine and dried (MgSO4). The solvent was evaporated to give the sub-title compound (2.40 g) as a yellow oil.

1. temperatureheating
2. temperatureThe reaction mixture was cooled
3. extractionextracted into ethyl acetate, which
4. washwas washed with water (3×)
5. dry with materialbrine and dried (MgSO4)
6. customThe solvent was evaporated