HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Methoxycarbonyl-2-trifluoroacetylaminobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-Amino-4-(methoxycarbonyl)benzoic acid | HCID 13349386 | — |
| Product | 4-Methoxycarbonyl-2-trifluoroacetylaminobenzoic acid | HCID 22934519 | 98% |
Reaction Steps
To a solution (15 ml) of 2-amino-4-methoxycarbonylbenzoic acid (3.00 g) in trifluoroacetic acid was added dropwise anhydrous trifluoroacetic acid (7 ml) at 0° C. This mixture was stirred for 1 hr. and poured into water. The crystals were collected by filtration to give 4-methoxycarbonyl-2-trifluoroacetylaminobenzoic acid (4.40 g, yield 98%). Recrystallization from hexane-ethyl acetate gave colorless prism crystals. melting point: 185–186° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223791B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-3492bafe3f894beb94ebcd7447494b31 |
| Source note | uspto-grants-2007_05 |