Hydrochloric Acid → HCID 9818965, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 4-[5-(4-trifluoromethylphenyl)-2-furyl]benzoate (1.80 g), 1 M aqueous sodium hydroxide solution (15 ml), tetrahydrofuran (50 ml) and ethanol (50 ml) was stirred at 60° C. for 1.5 hrs. After cooling, the reaction mixture was poured into water, and 1 M hydrochloric acid (40 ml) was added. The crystals were collected by filtration and recrystallized from ethanol to give 4-[5-(4-trifluoromethylphenyl)-2-furyl]benzoic acid (1.41 g, yield 85%) as a colorless crystalline powder. melting point: 270–271° C.

Provenance & Evidence