Hydrochloric Acid → HCID 21105732, compound

Participants

Reaction Steps

To a mixture of 3-[3-(4-trifluoromethylphenyl)-5-isoxazolyl]benzaldehyde (0.539 g), sodium dihydrogen phosphate (0.204 g), 2-methyl-2-butene (1.80 ml), acetonitrile (40 ml) and water (10 ml) was added an aqueous solution (5 ml) of sodium chlorite (0.769 g), and the mixture was stirred at room temperature for 1 hr. To this mixture was added sodium sulfite (1.5 g), and the mixture was stirred for 10 min. and poured into 1 M hydrochloric acid. The crystals were collected by filtration and recrystallized from ethanol to give 3-[3-(4-trifluoromethylphenyl)-5-isoxazolyl]benzoic acid (0.451 g, yield 80%) as a colorless crystalline powder. melting point: 272–273° C.

Provenance & Evidence