Hydrochloric Acid → 3-[5-(4-Trifluoromethylphenyl)-3-isoxazolyl]benzoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 3-[5-(4-trifluoromethylphenyl)-3-isoxazolyl]benzoate (1.04 g), 1 M aqueous sodium hydroxide solution (10 ml), tetrahydrofuran (30 ml) and methanol (30 ml) was stirred at 60° C. for 1 hr. After cooling, the reaction mixture was poured into water, and 1 M hydrochloric acid (20 ml) was added. The crystals were collected by filtration and recrystallized from ethanol to give 3-[5-(4-trifluoromethylphenyl)-3-isoxazolyl]benzoic acid (0.876 g, yield 88%) as a colorless crystalline powder. melting point: 276–277° C.

Provenance & Evidence