Hydrochloric Acid → HCID 21105758, compound

Participants

Reaction Steps

To a mixture of 4-[5-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-3-yl]benzaldehyde (1.30 g), sodium dihydrogen phosphate (0.51 g), 2-methyl-2-butene (1.3 ml), water (15 ml), t-butanol (15 ml) and tetrahydrofuran (30 ml) was slowly added sodium chlorite (0.75 g) at 0° C., and the mixture was stirred for 2 hrs. To the reaction mixture was added conc. hydrochloric acid (3 ml), and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated. The obtained colorless crystals were recrystallized from tetrahydrofuran-hexane to give 4-[5-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid (1.21 g, yield 89%). melting point: 286–287° C.

Provenance & Evidence