反应详情

A mixture of methyl 4-chloroformylbenzoate (1.17 g), 5-(4-t-butylphenyl)-1H-tetrazole (1.00 g) and pyridine (10 ml) was heated under reflux for 1 hr. After cooling, water was added to the mixture. The crystals were collected by filtration and dissolved in ethyl acetate. This solution was washed with 1 M hydrochloric acid, water and saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was washed with cold hexane to give methyl 4-[5-(4-t-butylphenyl)-1,3,4-oxadiazol-2-yl]benzoate (1.51, yield 92%). Recrystallization from hexane-tetrahydrofuran gave colorless prism crystals. melting point: 210–211° C.

1. temperaturewas heated
2. temperatureunder reflux for 1 hr
3. temperatureAfter cooling
4. filtrationThe crystals were collected by filtration
5. dissolutiondissolved in ethyl acetate
6. washThis solution was washed with 1 M hydrochloric acid, water and saturated brine
7. dry with materialdried over anhydrous magnesium sulfate
8. concentrationconcentrated
9. washThe residue was washed with cold hexane