Hydrochloric Acid → HCID 21105759, compound

Participants

Reaction Steps

A mixture of methyl 4-[5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl]benzoate (0.800 g), 1 M aqueous sodium hydroxide solution (4.6 ml) and tetrahydrofuran (5 ml) was heated under reflux for 1.5 hrs. After cooling, 1 M hydrochloric acid was added to acidify the mixture. The crystals were collected by filtration to give 4-[5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl]benzoic acid (0.71 g, yield 92%). Recrystallization from hexane-ethyl acetate gave colorless prism crystals. melting point: >300° C.

Provenance & Evidence