Hydrochloric Acid → HCID 21105753, compound

Participants

Reaction Steps

To a mixture of 4-[5-(2-nitrophenyl)-1,3,4-oxadiazol-2-yl]benzaldehyde (0.930 g), sodium dihydrogen phosphate (0.490 g), 2-methyl-2-butene (1.95 ml), t-butanol (20 ml), tetrahydrofuran (20 ml) and water (20 ml) was added sodium chlorite (0.570 g) at 0° C., and the mixture was stirred for 3 hrs. To the mixture was added an aqueous sodium sulfite solution, and the mixture was stirred at room temperature for 15 min., and acidified by adding 1 M hydrochloric acid. The crystals were collected by filtration to give 4-[5-(2-nitrophenyl)-1,3,4-oxadiazol-2-yl]benzoic acid (1.00 g, yield 78%). Recrystallization from hexane-tetrahydrofuran gave pale-yellow prism crystals. melting point: 239–240° C.

Provenance & Evidence