HCID 22934560, compound → HCID 22934557, compound

Participants

Reaction Steps

A mixture of ethyl 4-[5-(2-nitrophenyl)-1,3,4-oxadiazol-2-yl]benzoate (2.00 g), 5%.palladium on carbon (0.4 g) and tetrahydrofuran (50 ml) was stirred under a hydrogen atmosphere at room temperature and normal pressure for 30 min. Palladium on carbon was filtered off, and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1, volume ratio) to give ethyl 4-[5-(2-aminophenyl)-1,3,4-oxadiazol-2-yl]benzoate (0.23 g, yield 62%). Recrystallization from hexane-ethyl acetate gave pale-yellow prism crystals. melting point: 174–175° C.

Provenance & Evidence