Hydrochloric Acid → HCID 21105751, compound

Participants

Reaction Steps

A mixture of ethyl 4-[5-(2-aminophenyl)-1,3,4-oxadiazol-2-yl]benzoate (0.17 g),. 1 M aqueous sodium hydroxide solution (1.1 ml) and tetrahydrofuran (2 ml) was heated under reflux for 30 min. After cooling, 1 M hydrochloric acid was added to acidify the mixture. The crystals were collected by filtration to give 4-[5-(2-aminophenyl)-1,3,4-oxadiazol-2-yl]benzoic acid (0.13 g, yield 87%). Recrystallization from hexane-tetrahydrofuran gave colorless prism crystals. melting point: >300° C.

Provenance & Evidence