HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1354463Generated: October 27, 2026
Methyl 4-carbamothioylbenzoate → Methyl 4-[5-(4-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl]benzoate
https://huagongshe.com/reaction/1354463
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 4-carbamothioylbenzoate | HCID 11401319 | — |
| Reactant | N-benzylidene-4-trifluoromethylbenzenecarbohydrazonoyl chloride | HCID 86593884 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-[5-(4-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl]benzoate | HCID 22934538 | 57% |
Reaction Steps
A mixture of N-benzylidene-4-trifluoromethylbenzenecarbohydrazonoyl chloride (1.55 g), methyl 4-thiocarbamoylbenzoate (0.976 g) and methanol (50 ml) was stirred at 50° C. for 2 hrs. After cooling, the crystals were collected by filtration to give methyl 4-[5-(4-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl]benzoate (1.03 g, yield 57%) as a colorless crystalline powder. melting point: 218–219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07223791B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-c6b70ee12ee84b749f89a8177368b91a |
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| Source note | uspto-grants-2007_05 |
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