Hydrochloric Acid → HCID 21105742, compound

Participants

Reaction Steps

A mixture of methyl 3-nitro-4-[3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-5-yl]benzoate (2.00 g), 1 M aqueous sodium hydroxide solution (10.2 ml) and tetrahydrofuran (10 ml) was heated under reflux for 1 hr. After cooling, 1 M hydrochloric acid was added to acidify the reaction mixture. The crystals were collected by filtration to give 3-nitro-4-[3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-5-yl]benzoic acid (1.84 g, yield 95%). Recrystallization from hexane-tetrahydrofuran gave pale-yellow prism crystals. melting point: 233–234° C.

Provenance & Evidence