Hydrochloric Acid → HCID 21105739, compound

Participants

Reaction Steps

A mixture of methyl 3-trifluoroacetylamino-4-[3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-5-yl]benzoate (0.800 g), 1 M aqueous sodium hydroxide solution (5.1 ml) and tetrahydrofuran (10 ml) was stirred at room temperature for 1 hr. After cooling, 1 M hydrochloric acid was added to acidify the reaction mixture. The crystals were collected by filtration to give 3-amino-4-[3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-5-yl]benzoic acid (0.570 g, yield 97%). Recrystallization from hexane-tetrahydrofuran gave colorless prism crystals. melting point: >300° C.

Provenance & Evidence