HCID 21105756, compound → HCID 21105740, compound

Participants

Reaction Steps

A mixture of 4-[5-(4-t-butylphenyl)-1,3,4-oxadiazol-2-yl]-3-nitrobenzoic acid (0.200 g), 5% palladium on carbon (0.200 g) and tetrahydrofuran (20 ml) was stirred under a hydrogen atmosphere at room temperature and normal pressure for 30 min. Palladium on carbon was filtered off, and the filtrate was concentrated. The residue was purified by silica gel column chromatography (ethyl acetate:methanol=20:1, volume ratio) to give 3-amino-4-[5-(4-t-butylphenyl)-1,3,4-oxadiazol-2-yl]benzoic acid (0.120 g, yield 67%). Recrystallization from hexane-ethyl acetate gave yellow prism crystals. melting point: 266–268° C.

Provenance & Evidence