Sulfuric Acid → HCID 21105734, compound

Participants

Reaction Steps

A mixture of 2-[3-(1,3-dioxolan-2-yl)phenyl]-5-(4-trifluoromethylphenyl)-1,3,4-oxadiazole (4.10 g), 0.5 M sulfuric acid (30 ml) and acetone (100 ml) was heated under reflux for 1 hr. After cooling, the reaction mixture was concentrated, and the residue was diluted with ethyl acetate. This solution was washed with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated to give 3-[5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl]benzaldehyde (3.58 g, yield 99%). Recrystallization from hexane-ethyl acetate gave colorless-prism crystals. melting point: 129–130° C.

Provenance & Evidence