Ammonium formate → HCID 178435259, compound

Participants

Reaction Steps

53 mg of 1-benzyl-5-(2-ethyl-5-fluoro-indan-2-yl)-imidazole, 20 mg of Pd/C, 51 mg of ammonium formate and 2 ml of ethanol were added under nitrogen atmosphere into a round-bottomed flask equipped with a thermometer and a stirring bar. The reaction mixture was stirred at reflux temperature for 6 hours. The mixture was filtered and the filter (Celite™) was washed with ethanol. The reaction mixture was placed back into a round-bottomed flask and an additional 20 mg of Pd/C and 51 mg of ammonium formate were added under nitrogen atmosphere. The mixture was heated to reflux temperature and refluxed for 2 hours. Then the mixture was cooled to room temperature and filtered. The filter (Celite™) was washed with ethanol and after evaporation to dryness, whereby 4-(2-ethyl-5-fluoro-indan-2-yl)-1H-imidazole was obtained. The analytical sample was purified using TLC-plates. The purity was measured by HPLC: 60%. Normally the crude product was used in the following step.

Provenance & Evidence