反应详情

温度

80 °C

A suspension of 2-(4-iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile (1.8 g, 4.63 mmol) in 4 M HCl dioxane (40 mL) was heated to 80° C. for 6 h and cooled to room temperature. The precipitate was filtered and dried. The crude product (1.08 g, 82%) was used for the next step without purification. LRMS (neg. ESI, (M−H)−) m/z 283.

1. temperaturecooled to room temperature
2. filtrationThe precipitate was filtered
3. customdried
4. customThe crude product (1.08 g, 82%) was used for the next step without purification