反应详情

To a suspension of (S)-2-[4-(1-hydroxymethyl-2-phenyl-ethylamino)-2-oxo-1,2-dihydro-pyridin-3-yl]-7-methyl-3H-benzimidazole-5-carbonitrile (0.8 g, 2.0 mmol) in ethanol (anhydrous, 80 mL) was bubbled HCl (anhydrous) at 0° C. until saturation. The mixture became a clear solution after a few minutes of bubbling and the solution was stirred at room temperature for 14 h. After concentration in vacuo, the crude product (0.89 g, 100%) was directly used for the next step without purification. LCMS (M+H)+ m/z 446 (t=1.55 min).

1. customwas bubbled HCl (anhydrous) at 0° C. until saturation
2. customafter a few minutes
3. customof bubbling
4. concentrationAfter concentration in vacuo
5. customthe crude product (0.89 g, 100%) was directly used for the next step without purification
6. customLCMS (M+H)+ m/z 446 (t=1.55 min)