Sodium Hydroxide → HCID 178484897, compound

Participants

Reaction Steps

To a solution of 2-{4-[2-(3-chloro-4-methoxy-phenyl)-2-methoxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7,N-dimethyl-3H-benzimidazole-5-carboxamidine (40 mg, 0.08 mmol) in methanol (5 mL) was added 2 N NaOH (0.5 mL) and the reaction mixture was stirred at room temperature for 14 h. After concentration in vacuo, the residue was purified by prep. HPLC to yield the title compound (7.2 mg, 19%) as oil. 1H NMR (300 MHz, CD3OD) δ 7.78 (1H, narrow d, J=1.6 Hz), 7.52 (1H, narrow d, J=2.1 Hz), 7.30–7.36 (3H, m), 6.99 (1H, d, J=8.5 Hz), 6.27 (1H, d, J=7.6 Hz), 4.94 (1H, t, J=5.9 Hz), 3.82 (3H, s), 3.68–3.72 (2H, m), 3.13 (3H, s), 2.63 (3H, s). LCMS (M+H)+ m/z 481 (t=1.44 min.).

Provenance & Evidence