p-Fluoronitrobenzene → (R)-N-[1-(4-Nitrophenyl)pyrrolidin-3-yl]acetamide

HRID 1354662Notes

Reaction equation

HRID 1354662 reaction equation
[NH:1]1[CH2:5][CH2:4][C@@H:3]([NH:6][C:7](=[O:9])[CH3:8])[CH2:2]1.F[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1>>[N+:17]([C:14]1[CH:15]=[CH:16][C:11]([N:1]2[CH2:5][CH2:4][C@@H:3]([NH:6][C:7](=[O:9])[CH3:8])[CH2:2]2)=[CH:12][CH:13]=1)([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 7016129(3R)-(+)-3-Acetamidopyrrolidine

Product 1

HCID 67147876(R)-N-[1-(4-Nitrophenyl)pyrrolidin-3-yl]acetamide

Procedure

(R)-N-pyrrolidin-3-ylacetamide was reacted with 4-fluoronitrobenzene by method C. This resulted in the product with the molecular weight of 249.27 (C12H15N3O3); MS (ESI): 250 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 249.27 (C12H15N3O3)

Sources & evidence

ORD record
ord-f432057d6ece4137b217a4ea49c4725a
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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