2-Chloro-5-nitropyridine → HCID 86594865, compound

HRID 1354676Notes

Reaction equation

HRID 1354676 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([NH:16][C:17]3[CH:22]=C[C:20]([N:23]4[CH2:27][CH2:26][C@H:25]([CH2:28][NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:24]4)=[CH:19][CH:18]=3)=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.ClC1C=CC([N+]([O-])=O)=C[N:39]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([N:23]4[CH2:27][CH2:26][C@H:25]([CH2:28][NH:29][C:30](=[O:36])[O:31][C:32]([CH3:34])([CH3:35])[CH3:33])[CH2:24]4)=[N:39][CH:22]=3)=[O:15])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 783082-Chloro-5-nitropyridineHCID 86594861HCID 86594861, compound

Product 1

HCID 86594865HCID 86594865, compound

Procedure

The synthetic sequence for preparing tert-butyl (R)-[1-(4-{[4-(4-chlorophenyl)piperidin-1-carbonyl]amino}phenyl)pyrrolidin-3-yl]methylcarbamate was carried out starting from 2-chloro-5-nitropyridine instead of 4-fluoronitrobenzene. This resulted in the product with the molecular weight of 514.07 (C27H36ClN5O3); MS (ESI): 514 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 514.07 (C27H36ClN5O3)

Sources & evidence

ORD record
ord-946065b1e75c47ee96960e4e1a1ee20e
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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