4-Butoxy-2-nitrobenzoic acid → HCID 86594873, compound

HRID 1354699Notes

Reaction equation

HRID 1354699 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:9]2)=[CH:4][C:3]=1[F:22].[CH2:23]([O:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](O)=[O:33])=[C:30]([N+:37]([O-])=O)[CH:29]=1)[CH2:24][CH2:25][CH3:26]>>[NH2:37][C:30]1[CH:29]=[C:28]([O:27][CH2:23][CH2:24][CH2:25][CH3:26])[CH:36]=[CH:35][C:31]=1[C:32]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:9]2)=[CH:4][C:3]=1[F:22])=[O:33]

Participants

3

Reactant 2

HCID 211054734-Butoxy-2-nitrobenzoic acidHCID 68977926HCID 68977926, compound

Product 1

HCID 86594873HCID 86594873, compound

Procedure

tert-Butyl [1-(4-amino-3-fluorophenyl)pyrrolidin-3-yl]methylcarbamate was reacted with 4-butoxy-2-nitrobenzoic acid by method E, followed by hydrogenation. This resulted in the product with the molecular weight of 500.62 (C27H37FN4O4); MS (ESI): 501 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 500.62 (C27H37FN4O4)

Sources & evidence

ORD record
ord-d79f245b321a483bac1ccb6a51106b62
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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