反应详情

4-Cyclohexylcarboxylic acid (5.0 g) and 4-nitrophenylisocyanate (4.0 g) were stirred in toluene (150 ml) for 3 hours and then left to stand overnight. The precipitate was filtered off with suction and washed with diethyl ether. The resulting amide was ethylated by method F and hydrogenated by method B. This resulted in the product with the molecular weight of 308.43 (C20H24N2O); MS (ESI): 309 (M+H+).

1. waitleft
2. filtrationThe precipitate was filtered off with suction
3. washwashed with diethyl ether
4. customThis resulted in the product with the molecular weight of 308.43 (C20H24N2O)