Acetic Anhydride → HCID 21105616, compound

HRID 1354710Notes

Reaction equation

HRID 1354710 reaction equation
[CH:1]1([C:7]2[CH:30]=[CH:29][C:10]([C:11]([N:13]([CH3:28])[C:14]3[CH:19]=[CH:18][C:17]([N:20]4[CH2:24][CH:23]([NH:25][CH3:26])[CH2:22][C:21]4=[O:27])=[CH:16][CH:15]=3)=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:31](OC(=O)C)(=[O:33])[CH3:32]>N1C=CC=CC=1>[C:31]([CH2:26][NH:25][CH:23]1[CH2:24][N:20]([C:17]2[CH:18]=[CH:19][C:14]([N:13]([CH3:28])[C:11](=[O:12])[C:10]3[CH:29]=[CH:30][C:7]([CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)=[CH:8][CH:9]=3)=[CH:15][CH:16]=2)[C:21](=[O:27])[CH2:22]1)(=[O:33])[CH3:32]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 21105492HCID 21105492, compound

Product 1

HCID 21105616HCID 21105616, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-Cyclohexyl-N-methyl-N-[4-(4-methylamino-2-oxopyrrolidin-1-yl)phenyl]benzamide (101 mg) was mixed with pyridine (20 mg) and acetic anhydride (25 mg) and, after 3 hours, volatile fractions were removed in vacuo. This resulted in the product with the molecular weight of 447.58 (C27H33N3O3); MS (ESI): 448 (M+H+).

Workup

  1. customvolatile fractions were removed in vacuo
  2. customThis resulted in the product with the molecular weight of 447.58 (C27H33N3O3)

Sources & evidence

ORD record
ord-614e1e929e6640c08039446692b3f14f
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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