4-(2,4-difluorophenyl)benzoic Acid → HCID 58867032, compound

HRID 1354719Notes

Reaction equation

HRID 1354719 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:17])=O)=[CH:11][CH:10]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:29][CH2:28][CH:27]([N:30]([CH3:32])[CH3:31])[CH2:26]2)=[CH:21][CH:20]=1>>[CH3:31][N:30]([CH3:32])[CH:27]1[CH2:28][CH2:29][N:25]([C:22]2[CH:23]=[CH:24][C:19]([NH:18][C:15]([C:12]3[CH:11]=[CH:10][C:9]([C:3]4[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=4[F:1])=[CH:14][CH:13]=3)=[O:17])=[CH:20][CH:21]=2)[CH2:26]1

Participants

3

Reactant 2

HCID 27582644-(2,4-difluorophenyl)benzoic AcidHCID 219165911-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine

Product 1

HCID 58867032HCID 58867032, compound

Procedure

2′,4′-Difluorobiphenyl-4-carboxylic acid was reacted with [1-(4-aminophenyl)pyrrolidin-3-yl]dimethylamine by method E-a. This resulted in the product with the molecular weight of 421.20 (C25H25F2N3O); MS (ESI): 422 (M+H+) as hydrotrifluoroacetate.

Workup

  1. customThis resulted in the product with the molecular weight of 421.20 (C25H25F2N3O)

Sources & evidence

ORD record
ord-cbae318a17364292b4c276ea7e536c42
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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