Benzoic acid, 4-(acetyloxy)- → 4-[4-(3-Dimethylaminopyrrolidin-1-yl)phenylcarbamoyl]phenyl Acetate

HRID 1354743Notes

Reaction equation

HRID 1354743 reaction equation
[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:25][CH2:24][CH:23]([N:26]([CH3:28])[CH3:27])[CH2:22]2)=[CH:17][CH:16]=1>>[C:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([C:9](=[O:11])[NH:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:25][CH2:24][CH:23]([N:26]([CH3:28])[CH3:27])[CH2:22]3)=[CH:17][CH:16]=2)=[CH:12][CH:13]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 16865Benzoic acid, 4-(acetyloxy)-HCID 219165911-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine

Product 1

HCID 211054604-[4-(3-Dimethylaminopyrrolidin-1-yl)phenylcarbamoyl]phenyl Acetate

Procedure

4-Acetoxybenzoic acid was reacted with [1-(4-aminophenyl)pyrrolidin-3-yl]dimethylamine by method E-b. This resulted in the product with the molecular weight of 367.19 (C21H25N3O3); MS (ESI): 368 (M+H+) as hydrotrifluoroacetate.

Workup

  1. customThis resulted in the product with the molecular weight of 367.19 (C21H25N3O3)

Sources & evidence

ORD record
ord-d5717b5b27b142348eb335499181dfea
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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