HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Chloro-1',2',3',6'-tetrahydro-2,4'-bipyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl 4-(5-chloro-2-pyridyl)-3,6-dihydro-2H-pyridine-1-carboxylate | HCID 21105685 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 5-Chloro-1',2',3',6'-tetrahydro-2,4'-bipyridine | HCID 21105524 | — |
Reaction Steps
A solution of tert-butyl 5-chloro-3′,6′-dihydro-2′H-[2,4′]bipyridine-1′-carboxylate (50 mg) in chloroform (2.4 ml) was mixed with hydrogen chloride (4N in dioxane; 0.8 ml) and the mixture was concentrated after 13 hours. This resulted in the product with the molecular weight of 194.67 (C10H11ClN2); MS (ESI): 195 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223788B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0a84ec66631f478fb795247ee745dbec |
| Source note | uspto-grants-2007_05 |