反应详情

Piperidine-4-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide (30 mg), 2,5-dichloropyridine (30 mg) and tributylamine (0.2 ml) were heated at 160° C. for 2 hours. The cooled crude mixture was washed with heptane and purified by chromatography (silica gel, eluent: ethyl acetate/ammonia (3N in methanol)). This resulted in the product with the molecular weight of 427.98 (C23H30ClN5O); MS (ESI): 428 (M+H+).

1. temperatureThe cooled crude mixture
2. washwas washed with heptane
3. custompurified by chromatography (silica gel, eluent: ethyl acetate/ammonia (3N in methanol))
4. customThis resulted in the product with the molecular weight of 427.98 (C23H30ClN5O)