Tributylamine → HCID 58866598, 화합물

HRID 1354750노트

반응식

HRID 1354750 반응식
[CH3:1][N:2]([CH3:23])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[O:16])=[CH:10][CH:9]=2)[CH2:4]1.Cl[C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=1.C(N(CCCC)CCCC)CCC>>[CH3:1][N:2]([CH3:23])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]([NH:14][C:15]([CH:17]3[CH2:22][CH2:21][N:20]([C:25]4[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=4)[CH2:19][CH2:18]3)=[O:16])=[CH:12][CH:13]=2)[CH2:4]1

참가 물질

4

반응물 3

HCID 7622TributylamineHCID 276852,5-DichloropyridineHCID 67147939Piperidine-4-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide

생성물 1

HCID 58866598HCID 58866598, 화합물

실험 절차

Piperidine-4-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide (30 mg), 2,5-dichloropyridine (30 mg) and tributylamine (0.2 ml) were heated at 160° C. for 2 hours. The cooled crude mixture was washed with heptane and purified by chromatography (silica gel, eluent: ethyl acetate/ammonia (3N in methanol)). This resulted in the product with the molecular weight of 427.98 (C23H30ClN5O); MS (ESI): 428 (M+H+).

후처리

  1. temperatureThe cooled crude mixture
  2. washwas washed with heptane
  3. custompurified by chromatography (silica gel, eluent: ethyl acetate/ammonia (3N in methanol))
  4. customThis resulted in the product with the molecular weight of 427.98 (C23H30ClN5O)

출처 및 근거

ORD 기록
ord-97a80ffce1fe46aba7eb8753bb79cee5
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223788B2

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