(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 86594883, compound

HRID 1354760Notes

Reaction equation

HRID 1354760 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[CH2:11][OH:12].[NH:13]1[CH2:17][CH2:16][C@@H:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:14]1>>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([N:13]2[CH2:17][CH2:16][C@@H:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[CH2:14]2)=[C:3]([CH2:11][OH:12])[CH:4]=1

Participants

3

Reactant 2

HCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 4437169(2-Fluoro-5-nitrophenyl)methanol

Product 1

HCID 86594883HCID 86594883, compound

Procedure

(2-Fluoro-5-nitrophenyl)methanol was treated with tert-butyl (R)-(+)-pyrrolidin-3-ylcarbamate and subsequently hydrogenated by method C-c. This resulted in the product with the molecular weight of 307.40 (C16H25N3O3); MS (ESI): 308 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 307.40 (C16H25N3O3)

Sources & evidence

ORD record
ord-996bba446f3d43ddac3a03b9e57b2dfc
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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