p-Fluoronitrobenzene → HCID 21105564, compound

HRID 1354763Notes

Reaction equation

HRID 1354763 reaction equation
[OH:1][C@@H:2]1[CH2:6][NH:5][CH2:4][C@H:3]1[N:7]([CH3:11])[C:8](=[O:10])[CH3:9].F[C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][CH:14]=1>>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([N:5]2[CH2:6][CH:2]([OH:1])[CH:3]([N:7]([CH3:11])[C:8](=[O:10])[CH3:9])[CH2:4]2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 43595975HCID 43595975, compound

Product 1

HCID 21105564HCID 21105564, compound

Procedure

trans-N-(4-Hydroxypyrrolidin-3-yl)-N-methylacetamide was reacted with 4-fluoronitrobenzene by method C, and the product was subsequently hydrogenated by method B. This resulted in the product with the molecular weight of 249.32 (C13H19N3O2); MS (ESI): 250 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 249.32 (C13H19N3O2)

Sources & evidence

ORD record
ord-6a41074fc678454f813ed22b446d9a76
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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