1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid → Piperidine-4-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide

HRID 1354771Notes

Reaction equation

HRID 1354771 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:28][CH2:27][CH:26]([N:29]([CH3:31])[CH3:30])[CH2:25]2)=[CH:20][CH:19]=1>>[CH3:30][N:29]([CH3:31])[CH:26]1[CH2:27][CH2:28][N:24]([C:21]2[CH:22]=[CH:23][C:18]([NH:17][C:14]([CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[O:16])=[CH:19][CH:20]=2)[CH2:25]1

Participants

3

Reactant 2

HCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acidHCID 219165911-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine

Product 1

HCID 67147939Piperidine-4-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide

Procedure

Piperidine-1,4-dicarboxylic acid mono-tert-butyl ester was reacted with [1-(4-aminophenyl)pyrrolidin-3-yl]dimethylamine by method E, and the product was then treated by method G. This resulted in the product with the molecular weight of 316.45 (C18H28N4O); MS (ESI): 317 (M+H+).

Workup

  1. additionthe product was then treated by method G
  2. customThis resulted in the product with the molecular weight of 316.45 (C18H28N4O)

Sources & evidence

ORD record
ord-74c9103e47104b6a8bd4bc646239e4b7
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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