Monomethyl terephthalate → N-[4-(3-Dimethylaminopyrrolidin-1-yl)phenyl]terephthalamic Acid Methyl Ester

HRID 1354784Notes

Reaction equation

HRID 1354784 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]([CH3:15])[CH3:14])[CH2:9]2)=[CH:4][CH:3]=1.[CH3:16][O:17][C:18](=[O:28])[C:19]1[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=1>>[CH3:16][O:17][C:18](=[O:28])[C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([N:8]3[CH2:12][CH2:11][CH:10]([N:13]([CH3:15])[CH3:14])[CH2:9]3)=[CH:4][CH:3]=2)=[O:24])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 15513Monomethyl terephthalateHCID 219165911-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine

Product 1

HCID 67148143N-[4-(3-Dimethylaminopyrrolidin-1-yl)phenyl]terephthalamic Acid Methyl Ester

Procedure

[1-(4-Aminophenyl)pyrrolidin-3-yl]dimethylamine was reacted with terephthalic acid monomethyl ester by method E. This resulted in the product with the molecular weight of 367.45 (C21H25N3O3); MS (ESI): 368 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 367.45 (C21H25N3O3)

Sources & evidence

ORD record
ord-def722487b6e4c089982b0e6a12742ca
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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