Potassium Hydroxide → HCID 21105435, compound

HRID 1354788Notes

Reaction equation

HRID 1354788 reaction equation
[OH-].[K+].[F:3][C:4]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:5]=1[O:6][C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][CH:8]=1>C1COCC1.O>[F:3][C:4]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:5]=1[O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]([OH:13])=[O:12])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18695463HCID 18695463, compound

Product 1

HCID 21105435HCID 21105435, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Conditions

Temperature
110 °C

Procedure

0.518 g of potassium hydroxide was added to a solution of 0.428 g of ethyl 4-(2,4-difluorophenoxy)benzoate in 2 ml of THF/water (1:1). The solution was heated at 110° C. for 6 hours. The THF was then removed in vacuo, and the aqueous phase was freeze dried and purified by preparative HPLC. This resulted in the product with the molecular weight of 250.04 (C13H8F2O3); MS (ESI): 251 (M+H+).

Workup

  1. customThe THF was then removed in vacuo
  2. customdried
  3. custompurified by preparative HPLC
  4. customThis resulted in the product with the molecular weight of 250.04 (C13H8F2O3)

Sources & evidence

ORD record
ord-397a8712fc8b484b9d424b03d4b44e17
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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