Hydrochloric Acid → HCID 178507473, compound

Participants

Reaction Steps

A mixture of 4-amino-3-nitrobenzonitrile (8-1) (163 mg, 1.0 mmol), NaN3 (1.5 mL of 2.0 M solution, 3.0 mmol) ZnBr2 (1.0 mL of 2.0 M solution, 2.0 mmol) was microwaved (Smith-Synthesizer) at 160° C. for 15 min with stirring. After this time, the reaction was completion according to LCMS. The reaction mixture was acidified to pH=2 with concentrated HCl. The precipitated product was collected by filtration and washed with water (2×3 mL). After drying, 179 mg (87%) of desired product were obtained as a yellow solid. Analytical LCMS: single peak, (214 nm), 1.909 min; 1H NMR (500 MHz, DMSO-d6): δ 8.70 (d, J=2.0 Hz, 1H), 8.02 (dd, J=8.9, 2.0 Hz, 1H), 7.92 (s, 2H), 7.21 (d, J=8.9 Hz, 1H).

Provenance & Evidence