3-Pyridinecarboxaldehyde, 2-amino- → HCID 21103207, compound

Participants

Reaction Steps

4-(Phenylacetyl)benzoic acid (1.0 g, 4.16 mmole) and 2-aminonicotinaldehyde (508 mg, 4.16 mmole) were combined in HOAc (5 mL) in a sealed microwave vessel. The mixture was microwave irradiated to 200° C. internal temperature for 2 hr. The mixture was concentrated. Flash column (5% MeOH/CH2Cl2) gave the title compound as a pale yellow solid (9-1): 1H-NMR (500 MHz, DMSO-d6) δ 13.05 (bs, 1 H), 9.15 (dd, J=1.95, 2.20 Hz, 1 H), 8.58 (m, 2 H), 7.88 (d, J=8.06 Hz, 2 H), 7.71 (m, 1 H), 7.53 (d, J=8.05 Hz, 2 H), 7.36 (m, 3 H), 7.30 (m, 2 H).

Provenance & Evidence