Triethylamine → HCID 21103206, compound

Participants

Reaction Steps

To a solution of [4-(3-phenyl-1,8-naphthyridin-2-yl)phenyl]methanol (9-2) (289 mg, 0.925 mmole) in DMSO (2 mL) was added Et3N (1.3 mL, 9.25 mmole) then a solution of pyridine-SO3 (442 mg, 2.78 mmole) in DMSO (2 mL). After 1 hr the mixture was diluted with saturated NaHCO3 and extracted with EtOAc (3×). The combined organic layers were washed with H2O (2×), brine then dried (MgSO4), filtered, and concentrated to give the title compound as a greenish foam which was sufficiently for use in the next step: 1H-NMR (500 MHz, CDCl3) δ 10.02 (s, 1), 9.19 (dd, J=1.95, 2.20 Hz, 1 H), 8.28 (dd, J=1.95, 6.10 Hz, 1 H), 8.26 (s, 1 H), 7.79 (d, J=8.05 Hz, 2 H), 7.73 (d, J=8.30 Hz, 2 H), 7.56 (m, 1H), 7.35 (m, 3 H), 7.27 (m, 2 H).

Provenance & Evidence