HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → 3-(Dimethylamino)-1-(4-methylphenyl)-2-phenylprop-2-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 1-(4-Methylphenyl)-2-phenylethan-1-one | HCID 228016 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(Dimethylamino)-1-(4-methylphenyl)-2-phenylprop-2-en-1-one | HCID 67218698 | — |
Reaction Steps
A solution of 1-(4-methylphenyl)-2-phenylethanone (11-1) (8.4 g, 39.95 mmol) and N,N-dimethylformamide dimethylacetal (11.9 g, 99.87 mmol) in DMF (40 mL) was heated to 100° C. for 1 h. Concentrated in vacuo to give crude 3-(dimethylamino)-1-(4-methylphenyl)-2-phenylprop-2-en-1-one (11-2) as a red oil. LRMS m/z (M+H) Calcd: 266.4, found: 266.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223738B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-6b907e0722174143bbc9377224c5b7ad |
| Source note | uspto-grants-2007_05 |