Potassium Carbonate → HCID 21103673, compound

Participants

Reaction Steps

Compound 37 (1 g, 3 mmol) was dissolved in THF (100 mL). K2CO3 (2 g, 15 mmol) was added followed by 2-amino-5-nitro-phenol (693 mg, 4.5 mmol). The reaction mixture was allowed to stir at room temperature overnight. K2CO3 was filtered off though filter paper. The solvent was removed under reduced pressure. Liquid-liquid extraction was performed using CHCl3 (100 mL) and H2O (50 mL). The organic layer was dried over MgSO4. After MgSO4 was filtered off, the solvent was removed under reduced pressure. The residue was purified by flash chromatography to give compound 39 (786 mg, 55.7% isolated yield). LC-MS (ESI): m/e=471.1 [M+1]+

Provenance & Evidence