HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-dibromo-5-nitrobenzene → 3,5-Dibromoaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-dibromo-5-nitrobenzene | HCID 238711 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3,5-Dibromoaniline | HCID 221512 | 85.7% |
Reaction Steps
In a scale up reaction using the same procedure as described above, 5 g (17.9 mmol) of 3,5-dibromonitrobenzene (262), 30 mL of TiCl3 (30% wt. in 2.0 N aqueous HCl) and AcOH (125 mL) were used. After 4 h reaction and subsequent work-up, 3.85 g (85.7% yield) of 3,5-dibromoaniline (273) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223759B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-fc1d7fc559f44c58b1b78acb386c8451 |
| Source note | uspto-grants-2007_05 |