Ethanol → 3-Cyclopentyl-2-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-propionic acid ethyl ester

Temperature

25 °C

A solution of 3-cyclopentyl-2-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-propionic acid (1.29 g, 3.89 mmol) in ethanol (25 mL) was treated slowly with concentrated sulfuric acid (0.01 mL). The resulting reaction mixture was heated under reflux for 48 h. The reaction mixture was allowed to cool to 25° C. and then concentrated in vacuo. The residue was dissolved in ethyl acetate (35 mL). The organic layer was washed with a saturated aqueous sodium bicarbonate solution (1×15 mL), water (1×15 mL), and a saturated aqueous sodium chloride solution (3×20 mL). The organic layer was then dried over magnesium sulfate and sodium sulfate, filtered, and concentrated in vacuo to afford 3-cyclopentyl-2-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-propionic acid ethyl ester (1.39 g, 94.8%) as yellow oil: EI-HRMS m/e calcd for C18H23F3O2S (M+) 360.1370, found 360.1370.

1. customThe resulting reaction mixture
2. temperaturewas heated
3. temperatureunder reflux for 48 h
4. concentrationconcentrated in vacuo
5. dissolutionThe residue was dissolved in ethyl acetate (35 mL)
6. washThe organic layer was washed with a saturated aqueous sodium bicarbonate solution (1×15 mL), water (1×15 mL)
7. dry with materialThe organic layer was then dried over magnesium sulfate and sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated in vacuo

ORD record

ord-a5ddade2b5e64152b59103902ce1953e

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07223868B2