Glycerol → HCID 69533241, compound

HRID 1355302Notes

Reaction equation

HRID 1355302 reaction equation
[B:1]([OH:4])([OH:3])[OH:2].[OH:5][CH2:6][CH:7]([CH2:9]O)[OH:8].[C:11]([NH2:20])(=[O:19])[C:12]1[C:13](=[CH:15][CH:16]=[CH:17][CH:18]=1)[OH:14]>C1(C)C=CC=CC=1>[C:11]([NH2:20])(=[O:19])[C:12]1[C:13](=[CH:15][CH:16]=[CH:17][CH:18]=1)[OH:14].[B:1]([O:4][CH2:9][CH:7]([CH2:6][OH:5])[OH:8])([OH:3])[OH:2]

Participants

5

Reactant 3

HCID 753GlycerolHCID 5147SalicylamideHCID 7628Boric Acid

Product 1

HCID 69533241HCID 69533241, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Salicylamide/glycerol borate was prepared as follows. Boric acid (10.3 grams), glycerol (15.3 grams), and salicylamide (22.9 grams) were added to a 250 milliliter flask. One hundred fifty milliliters of toluene was then added. The reaction was allowed to proceed overnight at 110° C., and the byproduct water (˜9 grams) was continuously removed from the reaction by azeotropic distillation. The final solution was evaporated to remove toluene under vacuum, and a yellowish resinous product (˜40 grams) of salicylamide/glycerol borate was obtained.

Workup

  1. customSalicylamide/glycerol borate was prepared
  2. customthe byproduct water (˜9 grams) was continuously removed from the reaction by azeotropic distillation
  3. customThe final solution was evaporated
  4. customto remove toluene under vacuum

Sources & evidence

ORD record
ord-d83c7b65d05744529511575f6efacd63
Source dataset
uspto-grants-2003_07
Patent number
US06585816B1

Reaction notes

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