HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1355330Generated: November 1, 2026
Phosphorus tribromide → 4,6-Dimethyl-3-bromobenzofuran
https://huagongshe.com/reaction/1355330
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 4,6-Dimethyl-3(2H)-benzofuranone | HCID 595599 | — |
| Product | 4,6-Dimethyl-3-bromobenzofuran | HCID 10900287 | 60% |
Reaction Steps
4,6-dimethyl-3-benzofuranone (0.09 moles) was slowly added in phosphorus tribromide (30 ml), previously heated to 100° C. The mix is cautiously treated with ice, extracted with methylenechloride. The organic phase is made anhydrous (Na2SO4) and freed from the solvent under reduced pressure to produce 4,6-dimethyl-3-bromobenzofuran (60% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06586357B1 |
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| Source dataset | uspto-grants-2003_07 |
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| ORD ID | ord-003a927941ee4a008e2c7256b1af2ced |
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| Source note | uspto-grants-2003_07 |
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