HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Diisopropylethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 67027098 | HCID 67027098 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Diisopropylethylamine | HCID 81531 | — |
Reaction Steps
Bromo-pyrazines II-4 react with tetrahydro-benzo or thieno-azepine compounds III or their hydrochlorides in solvents like N,N-dimethylformamide, acetonitrile, acetone or dimethylsulfoxide in the presence of a base like potassium carbonate or a tertiary amine like diisopropyl-ethylamine at temperatures between room temperature and 80° C. to form the desired 3-(tetrahydro-benzo- or thieno-azepine-3-yl)-pyrazine-2-carbonitriles I-6. 3-(Tetrahydro-benzo- or thieno-azepine-3-yl)-pyrazine-2-carbonitriles of formula I-7 can be prepared according to scheme 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586422B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-5f9ad93222d248d18e69e09a4bb2a43f |
| Source note | uspto-grants-2003_07 |