Ethanolamine → HCID 9836314, compound

HRID 1355355Notes

Reaction equation

HRID 1355355 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]([C:20]#[N:21])=[C:7]([N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=3[CH2:11][CH2:10]2)[N:8]=1.[CH2:22]([CH2:24][NH2:25])[OH:23]>O1CCOCC1>[OH:23][CH2:22][CH2:24][NH:25][C:3]1[N:4]=[N:5][C:6]([C:20]#[N:21])=[C:7]([N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=3[CH2:11][CH2:10]2)[N:8]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 18506776HCID 18506776, compound

Product 1

HCID 9836314HCID 9836314, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure as described in example 4 the 3-methylsulfanyl-5-(1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-[1,2,4]triazine-6-carbonitrile was reacted with ethanolamine in dioxane at 140° C. overnight to give 3-(2-hydroxy-ethylamino)-5 -(1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-[1,2,4]triazine-6-carbonitrile as a light yellow solid; MS: 311 (M+H)+.

Sources & evidence

ORD record
ord-cbbfff23d605470ba36d9764ebbe7887
Source dataset
uspto-grants-2003_07
Patent number
US06586422B2

Reaction notes

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